Ontology highlight
ABSTRACT:
SUBMITTER: Schwab RA
PROVIDER: S-EPMC2829160 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Schwab Rebekka A RA Blackford Andrew N AN Niedzwiedz Wojciech W
The EMBO journal 20100107 4
Fanconi anaemia is a chromosomal instability disorder associated with cancer predisposition and bone marrow failure. Among the 13 identified FA gene products only one, the DNA translocase FANCM, has homologues in lower organisms, suggesting a conserved function in DNA metabolism. However, a precise role for FANCM in DNA repair remains elusive. Here, we show a novel function for FANCM that is distinct from its role in the FA pathway: promoting replication fork restart and simultaneously limiting ...[more]