Ontology highlight
ABSTRACT:
SUBMITTER: Sinha S
PROVIDER: S-EPMC2829167 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20100114 4
How tumour suppressor p53 bifurcates cell cycle arrest and apoptosis and executes these distinct pathways is not clearly understood. We show that BAX and PUMA promoters harbour an identical MAR element and are transcriptional targets of SMAR1. On mild DNA damage, SMAR1 selectively represses BAX and PUMA through binding to the MAR independently of inducing p53 deacetylation through HDAC1. This generates an anti-apoptotic response leading to cell cycle arrest. Importantly, knockdown of SMAR1 induc ...[more]