Ontology highlight
ABSTRACT:
SUBMITTER: Curran JE
PROVIDER: S-EPMC2829432 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Curran Joanne E JE Jowett Jeremy B M JB Abraham Lawrence J LJ Diepeveen Luke A LA Elliott Katherine S KS Dyer Thomas D TD Kerr-Bayles Lyndal J LJ Johnson Matthew P MP Comuzzie Anthony G AG Moses Eric K EK Walder Ken R KR Collier Gregory R GR Blangero John J Kissebah Ahmed H AH
Human genetics 20091028 2
Given their involvement in processes necessary for life, mitochondrial damage and subsequent dysfunction can lead to a wide range of human diseases. Previous studies of both animal models and humans have suggested that presenilins-associated rhomboid-like protein (PARL) is a key regulator of mitochondrial integrity and function, and plays a role in cellular apoptosis. As a surrogate measure of mitochondrial integrity, we previously measured mitochondrial content in a Caucasian population consist ...[more]