Dataset Information

Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.

ABSTRACT:

Background

Hypereosinophilic syndrome (HES) is a heterogeneous group of rare disorders defined by persistent blood eosinophilia > or =1.5 x 10(9)/L, absence of a secondary cause, and evidence of eosinophil-associated pathology. With the exception of a recent multicenter trial of mepolizumab (anti-IL-5 mAb), published therapeutic experience has been restricted to case reports and small case series.

Objective

The purpose of the study was to collect and summarize baseline demographic, clinical, and laboratory characteristics in a large, diverse cohort of patients with HES and to review responses to treatment with conventional and novel therapies.

Methods

Clinical and laboratory data from 188 patients with HES, seen between January 2001 and December 2006 at 11 institutions in the United States and Europe, were collected retrospectively by chart review.

Results

Eighteen of 161 patients (11%) tested were Fip1-like 1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRA) mutation-positive, and 29 of 168 patients tested (17%) had a demonstrable aberrant or clonal T-cell population. Corticosteroid monotherapy induced complete or partial responses at 1 month in 85% (120/141) of patients with most remaining on maintenance doses (median, 10 mg prednisone equivalent daily for 2 months to 20 years). Hydroxyurea and IFN-alpha (used in 64 and 46 patients, respectively) were also effective, but their use was limited by toxicity. Imatinib (used in 68 patients) was more effective in patients with the FIP1L1-PDGFRA mutation (88%) than in those without (23%; P < .001).

Conclusion

This study, the largest clinical analysis of patients with HES to date, not only provides useful information for clinicians but also should stimulate prospective trials to optimize treatment of HES.

SUBMITTER: Ogbogu PU

PROVIDER: S-EPMC2829669 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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Publications

Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.

Ogbogu Princess U PU Bochner Bruce S BS Butterfield Joseph H JH Gleich Gerald J GJ Huss-Marp Johannes J Kahn Jean Emmanuel JE Leiferman Kristin M KM Nutman Thomas B TB Pfab Florian F Ring Johannes J Rothenberg Marc E ME Roufosse Florence F Sajous Marie-Helene MH Sheikh Javed J Simon Dagmar D Simon Hans-Uwe HU Stein Miguel L ML Wardlaw Andrew A Weller Peter F PF Klion Amy D AD

The Journal of allergy and clinical immunology 20091201 6

<h4>Background</h4>Hypereosinophilic syndrome (HES) is a heterogeneous group of rare disorders defined by persistent blood eosinophilia > or =1.5 x 10(9)/L, absence of a secondary cause, and evidence of eosinophil-associated pathology. With the exception of a recent multicenter trial of mepolizumab (anti-IL-5 mAb), published therapeutic experience has been restricted to case reports and small case series.<h4>Objective</h4>The purpose of the study was to collect and summarize baseline demographic ...[more]

PMID: 19910029

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Dataset Information

Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.

Background

Objective

Methods

Results

Conclusion

Publications

Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.

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