Dataset Information
Molecular optical imaging with radioactive probes.
Ontology highlight
ABSTRACT: Background
Optical imaging (OI) techniques such as bioluminescence and fluorescence imaging have been widely used to track diseases in a non-invasive manner within living subjects. These techniques generally require bioluminescent and fluorescent probes. Here we demonstrate the feasibility of using radioactive probes for in vivo molecular OI.Methodology/principal findings
By taking the advantages of low energy window of light (1.2-3.1 eV, 400-1000 nm) resulting from radiation, radionuclides that emit charged particles such as beta(+) and beta(-) can be successfully imaged with an OI instrument. In vivo optical images can be obtained for several radioactive probes including 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG), Na(18)F, Na(131)I, (90)YCl(3) and a (90)Y labeled peptide that specifically target tumors.Conclusions/significance
These studies demonstrate generalizability of radioactive OI technique. It provides a new molecular imaging strategy and will likely have significant impact on both small animal and clinical imaging.
SUBMITTER: Liu H
PROVIDER: S-EPMC2830426 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Molecular optical imaging with radioactive probes.
PloS one 20100301 3
<h4>Background</h4>Optical imaging (OI) techniques such as bioluminescence and fluorescence imaging have been widely used to track diseases in a non-invasive manner within living subjects. These techniques generally require bioluminescent and fluorescent probes. Here we demonstrate the feasibility of using radioactive probes for in vivo molecular OI.<h4>Methodology/principal findings</h4>By taking the advantages of low energy window of light (1.2-3.1 eV, 400-1000 nm) resulting from radiation, ra ...[more]