Ontology highlight
ABSTRACT:
SUBMITTER: Criollo A
PROVIDER: S-EPMC2830700 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Criollo Alfredo A Senovilla Laura L Authier Hélène H Maiuri Maria Chiara MC Morselli Eugenia E Vitale Ilio I Kepp Oliver O Tasdemir Ezgi E Galluzzi Lorenzo L Shen Shensi S Tailler Maximilien M Delahaye Nicolas N Tesniere Antoine A De Stefano Daniela D Younes Aména Ben AB Harper Francis F Pierron Gérard G Lavandero Sergio S Zitvogel Laurence L Israel Alain A Baud Véronique V Kroemer Guido G
The EMBO journal 20091203 3
In response to stress, cells start transcriptional and transcription-independent programs that can lead to adaptation or death. Here, we show that multiple inducers of autophagy, including nutrient depletion, trigger the activation of the IKK (IkappaB kinase) complex that is best known for its essential role in the activation of the transcription factor NF-kappaB by stress. Constitutively active IKK subunits stimulated autophagy and transduced multiple signals that operate in starvation-induced ...[more]