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Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity.

ABSTRACT: BACKGROUND: The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH). The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity. METHODS: We initially assessed association of five single nucleotide polymorphisms (SNPs) in FAAH with early onset extreme obesity in up to 521 German obese children and both parents. SNPs with nominal p-values 0.05). CONCLUSIONS: As we observed some evidence for an association of the FAAH variants rs2295632 rs324420 with early onset but not adult obesity, we conclude that the FAAH variants analyzed here at least do not seem to play a major role in the etiology of obesity within our samples.

SUBMITTER: Muller TD

PROVIDER: S-EPMC2830932 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity.

Müller Timo D TD Brönner Günter G Wandolski Melanie M Carrie Jophia J Nguyen Trang T TT Greene Brandon H BH Scherag André A Grallert Harald H Vogel Carla Ig CI Scherag Susann S Rief Winfried W Wichmann Hans-Erich HE Illig Thomas T Schäfer Helmut H Hebebrand Johannes J Hinney Anke A

BMC medical genetics 20100101

<h4>Background</h4>The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH). The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity.<h4>Methods</h4>We initially assessed association of five single nucleotide polymorphisms (SNPs) in FAAH with early onset extreme obesity in up to 521 German obese children and both parents. SNPs with nominal p-values <or= 0.1 were su ...[more]

PMID: 20044928

Dataset Information

Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity.

Publications

Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity.

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