Ontology highlight
ABSTRACT:
SUBMITTER: Lee Y
PROVIDER: S-EPMC2831284 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Lee Youngsoo Y Katyal Sachin S Li Yang Y El-Khamisy Sherif F SF Russell Helen R HR Caldecott Keith W KW McKinnon Peter J PJ
Nature neuroscience 20090726 8
Defective responses to DNA single strand breaks underlie various neurodegenerative diseases. However, the exact role of this repair pathway during the development and maintenance of the nervous system is unclear. Using murine neural-specific inactivation of Xrcc1, a factor that is critical for the repair of DNA single strand breaks, we found a profound neuropathology that is characterized by the loss of cerebellar interneurons. This cell loss was linked to p53-dependent cell cycle arrest and occ ...[more]