Ontology highlight
ABSTRACT:
SUBMITTER: Ouyang Z
PROVIDER: S-EPMC2831293 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Ouyang Zhiming Z Kumar Manish M Kariu Toru T Haq Shayma S Goldberg Martin M Pal Utpal U Norgard Michael V MV
Molecular microbiology 20091102 6
Summary Borrelia burgdorferi (Bb), the Lyme disease spirochaete, encodes a potential ferric uptake regulator (Fur) homologue, BosR (BB0647). Thus far, a role for BosR in Bb metabolism, gene regulation or pathogenesis has not been determined, largely due to the heretofore inability to inactivate bosR in low-passage, infectious Bb isolates. Herein, we report the generation of the first bosR-deficient mutant in a virulent strain of Bb. Whereas the bosR mutant persisted normally in ticks, the mutant ...[more]