Ontology highlight
ABSTRACT:
SUBMITTER: Lima WR
PROVIDER: S-EPMC2831853 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Lima Wânia R WR Parreira Kleber S KS Devuyst Olivier O Caplanusi Adrian A N'kuli Francisca F Marien Benoit B Van Der Smissen Patrick P Alves Pedro M S PM Verroust Pierre P Christensen Erik I EI Terzi Fabiola F Matter Karl K Balda Maria S MS Pierreux Christophe E CE Courtoy Pierre J PJ
Journal of the American Society of Nephrology : JASN 20100204 3
Epithelial polarization modulates gene expression. The transcription factor zonula occludens 1 (ZO-1)-associated nucleic acid binding protein (ZONAB) can shuttle between tight junctions and nuclei, promoting cell proliferation and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA), but whether it also represses epithelial differentiation is unknown. Here, during mouse kidney ontogeny and polarization of proximal tubular cells (OK cells), ZONAB and PCNA levels decreased in para ...[more]