Ontology highlight
ABSTRACT:
SUBMITTER: Gulley JL
PROVIDER: S-EPMC2832083 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Gulley James L JL Arlen Philip M PM Madan Ravi A RA Tsang Kwong-Yok KY Pazdur Mary P MP Skarupa Lisa L Jones Jacquin L JL Poole Diane J DJ Higgins Jack P JP Hodge James W JW Cereda Vittore V Vergati Matteo M Steinberg Seth M SM Halabi Susan S Jones Elizabeth E Chen Clara C Parnes Howard H Wright John J JJ Dahut William L WL Schlom Jeffrey J
Cancer immunology, immunotherapy : CII 20091105 5
A concurrent multicenter, randomized Phase II trial employing a recombinant poxviral vaccine provided evidence of enhanced median overall survival (OS) (p = 0.0061) in patients with metastatic castrate-resistant prostate cancer (mCRPC). The study reported here employed the identical vaccine in mCRPC to investigate the influence of GM-CSF with vaccine, and the influence of immunologic and prognostic factors on median OS. Thirty-two patients were vaccinated once with recombinant vaccinia containin ...[more]