Ontology highlight
ABSTRACT:
SUBMITTER: Groner AC
PROVIDER: S-EPMC2832679 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
PLoS genetics 20100305 3
Krüppel-associated box domain-zinc finger proteins (KRAB-ZFPs) are tetrapod-specific transcriptional repressors encoded in the hundreds by the human genome. In order to explore their as yet ill-defined impact on gene expression, we developed an ectopic repressor assay, allowing the study of KRAB-mediated transcriptional regulation at hundreds of different transcriptional units. By targeting a drug-controllable KRAB-containing repressor to gene-trapping lentiviral vectors, we demonstrate that KRA ...[more]