Ontology highlight
ABSTRACT:
SUBMITTER: Abrami L
PROVIDER: S-EPMC2832758 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Abrami Laurence L Bischofberger Mirko M Kunz Béatrice B Groux Romain R van der Goot F Gisou FG
PLoS pathogens 20100305 3
The anthrax toxin is a tripartite toxin, where the two enzymatic subunits require the third subunit, the protective antigen (PA), to interact with cells and be escorted to their cytoplasmic targets. PA binds to cells via one of two receptors, TEM8 and CMG2. Interestingly, the toxin times and triggers its own endocytosis, in particular through the heptamerization of PA. Here we show that PA triggers the ubiquitination of its receptors in a beta-arrestin-dependent manner and that this step is requ ...[more]