Increased incidence of rare codon clusters at 5' and 3' gene termini: implications for function.
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ABSTRACT:
SUBMITTER: Clarke TF
PROVIDER: S-EPMC2833160 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Increased incidence of rare codon clusters at 5' and 3' gene termini: implications for function.
Clarke Thomas F TF Clark Patricia L PL
BMC genomics 20100218
<h4>Background</h4>The process of translation can be affected by the use of rare versus common codons within the mRNA transcript.<h4>Results</h4>Here, we show that rare codons are enriched at the 5' and 3' termini of genes from E. coli and other prokaryotes. Genes predicted to be secreted show significant enrichment in 5' rare codon clusters, but not 3' rare codon clusters. Surprisingly, no correlation between 5' mRNA structure and rare codon usage was observed.<h4>Conclusions</h4>Potential func ...[more]
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