Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.
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ABSTRACT:
SUBMITTER: Teramoto T
PROVIDER: S-EPMC2833210 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.
Teramoto Takayuki T Sternick Laura A LA Kage-Nakadai Eriko E Sajjadi Shirine S Siembida Jakub J Mitani Shohei S Iwasaki Kouichi K Lambie Eric J EJ
PloS one 20100308 3
Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. eleg ...[more]
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