Dataset Information

Effects of task and coordinate frame of attention in area 7a of the primate posterior parietal cortex.

ABSTRACT: The activity of neurons in the primate posterior parietal cortex reflects the location of visual stimuli relative to the eye, body, and world, and is modulated by selective attention and task rules. It is not known however how these effects interact with each other. To address this question, we recorded neuronal activity from area 7a of monkeys trained to perform two variants of a delayed match-to-sample task. The monkeys attended a spatial location defined in either spatiotopic (world-centered) or retinotopic (eye-centered) coordinates. We found neuronal responses to be remarkably plastic depending on the task. In contrast to previous studies using the simple version of the delayed match-to-sample task, we discovered that after training in a task where the locus of attention shifted during the trial, neural responses were typically enhanced for a match stimulus. Our results further revealed that responses were mostly enhanced for stimuli matching in spatiotopic coordinates, although the proportion of neurons modulated by either coordinate frame was influenced by the behavioral task executed.

SUBMITTER: Rawley JB

PROVIDER: S-EPMC2833265 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effects of task and coordinate frame of attention in area 7a of the primate posterior parietal cortex.

Rawley Justin B JB Constantinidis Christos C

Journal of vision 20100127 1

The activity of neurons in the primate posterior parietal cortex reflects the location of visual stimuli relative to the eye, body, and world, and is modulated by selective attention and task rules. It is not known however how these effects interact with each other. To address this question, we recorded neuronal activity from area 7a of monkeys trained to perform two variants of a delayed match-to-sample task. The monkeys attended a spatial location defined in either spatiotopic (world-centered) ...[more]

PMID: 20143905

Similar Datasets

Project description:Recent models of human posterior parietal cortex (PPC) have variously emphasized its role in spatial perception, visuomotor control or directing attention. However, neuroimaging and lesion studies also suggest that the right PPC might play a special role in maintaining an alert state. Previously, assessments of right-hemisphere patients with hemispatial neglect have revealed significant overall deficits on vigilance tasks, but to date there has been no demonstration of a deterioration of performance over time--a vigilance decrement--considered by some to be a key index of a deficit in maintaining attention. Moreover, sustained attention deficits in neglect have not specifically been related to PPC lesions, and it remains unclear whether they interact with spatial impairments in this syndrome. Here we examined the ability of right-hemisphere patients with neglect to maintain attention, comparing them to stroke controls and healthy individuals. We found evidence of an overall deficit in sustaining attention associated with PPC lesions, even for a simple detection task with stimuli presented centrally. In a second experiment, we demonstrated a vigilance decrement in neglect patients specifically only when they were required to maintain attention to spatial locations, but not verbal material. Lesioned voxels in the right PPC spanning a region between the intraparietal sulcus and inferior parietal lobe were significantly associated with this deficit. Finally, we compared performance on a task that required attention to be maintained either to visual patterns or spatial locations, matched for task difficulty. Again, we found a vigilance decrement but only when attention had to be maintained on spatial information. We conclude that sustaining attention to spatial locations is a critical function of the human right PPC which needs to be incorporated into models of normal parietal function as well as those of the clinical syndrome of hemispatial neglect.

Dataset Information

Effects of task and coordinate frame of attention in area 7a of the primate posterior parietal cortex.

Publications

Effects of task and coordinate frame of attention in area 7a of the primate posterior parietal cortex.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets