Ontology highlight
ABSTRACT:
SUBMITTER: Zhou G
PROVIDER: S-EPMC2833348 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Zhou Guangyan G Wu Dong D Hermel Evan E Balogh Edina E Gochin Miriam M
Bioorganic & medicinal chemistry letters 20100125 5
A series of indole ring containing compounds were designed based on the structure of the gp41 complex in the region of the hydrophobic pocket. These compounds were synthesized using a Suzuki Coupling reaction, and evaluated using a fluorescence binding assay and cell-cell fusion assay. The observed inhibition constant of compound 7 was 2.1microM, and the IC(50) for cell-cell fusion inhibition was 1.1microM. Assay data indicated that 7 is a promising lead compound for optimization into an effecti ...[more]