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Design, synthesis, and evaluation of indole compounds as novel inhibitors targeting Gp41.

ABSTRACT: A series of indole ring containing compounds were designed based on the structure of the gp41 complex in the region of the hydrophobic pocket. These compounds were synthesized using a Suzuki Coupling reaction, and evaluated using a fluorescence binding assay and cell-cell fusion assay. The observed inhibition constant of compound 7 was 2.1microM, and the IC(50) for cell-cell fusion inhibition was 1.1microM. Assay data indicated that 7 is a promising lead compound for optimization into an effective low molecular weight fusion inhibitor.

SUBMITTER: Zhou G

PROVIDER: S-EPMC2833348 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Design, synthesis, and evaluation of indole compounds as novel inhibitors targeting Gp41.

Zhou Guangyan G Wu Dong D Hermel Evan E Balogh Edina E Gochin Miriam M

Bioorganic & medicinal chemistry letters 20100125 5

A series of indole ring containing compounds were designed based on the structure of the gp41 complex in the region of the hydrophobic pocket. These compounds were synthesized using a Suzuki Coupling reaction, and evaluated using a fluorescence binding assay and cell-cell fusion assay. The observed inhibition constant of compound 7 was 2.1microM, and the IC(50) for cell-cell fusion inhibition was 1.1microM. Assay data indicated that 7 is a promising lead compound for optimization into an effecti ...[more]

PMID: 20153190

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