Whole genome expression analysis reveals differential effects of TiO2 nanotubes on vascular cells.
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ABSTRACT:
SUBMITTER: Peng L
PROVIDER: S-EPMC2833360 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Whole genome expression analysis reveals differential effects of TiO2 nanotubes on vascular cells.
Peng Lily L Barczak Andrea J AJ Barbeau Rebecca A RA Xiao Yuanyuan Y LaTempa Thomas J TJ Grimes Craig A CA Desai Tejal A TA
Nano letters 20100101 1
The response of primary human endothelial (ECs) and vascular smooth muscle cells (VSMCs) to TiO2 nanotube arrays is studied through gene expression analysis. Microarrays revealed that nanotubes enhanced EC proliferation and motility, decreased VSMC proliferation, and decreased expression of molecules involved in inflammation and coagulation in both cell types. Networks generated from significantly affected genes suggest that cells may be sensing nanotopographical cues via pathways previously imp ...[more]
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