Ontology highlight
ABSTRACT:
SUBMITTER: Williams SN
PROVIDER: S-EPMC2834182 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Williams Stacey N SN Undieh Ashiwel S AS
Neuroreport 20090401 6
Recent studies showed that dopamine or D1 receptor-selective agonists increased brain-derived neurotrophic factor (BDNF) mRNA and protein expression in neuronal cultures, and this action was blocked by SCH23390. Moreover, SKF38393 activated Trk receptors and downstream signaling in striatal neurons. This study examined whether dopamine agonists induce the expression of BDNF protein in rat brain tissue. Acute slice preparations were incubated with dopamine agonists in Hibernate A medium and BDNF ...[more]