Ontology highlight
ABSTRACT:
SUBMITTER: Djuranovic S
PROVIDER: S-EPMC2834277 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20100110 2
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) bind to Argonaute (AGO) family proteins to form a related set of effector complexes that have diverse roles in post-transcriptional gene regulation throughout the eukaryotic lineage. Here sequence and structural analysis of the MID domain of the AGO proteins identified similarities with a family of allosterically regulated bacterial ligand-binding domains. We used in vitro and in vivo approaches to show that certain AGO proteins (those invol ...[more]