Ontology highlight
ABSTRACT:
SUBMITTER: Grimm C
PROVIDER: S-EPMC2834294 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Grimm Christian C Jörs Simone S Saldanha S Adrian SA Obukhov Alexander G AG Pan Bifeng B Oshima Kazuo K Cuajungco Math P MP Chase Peter P Hodder Peter P Heller Stefan S
Chemistry & biology 20100201 2
We conducted a high-throughput screen for small molecule activators of the TRPML3 ion channel, which, when mutated, causes deafness and pigmentation defects. Cheminformatics analyses of the 53 identified and confirmed compounds revealed nine different chemical scaffolds and 20 singletons. We found that agonists strongly potentiated TRPML3 activation with low extracytosolic [Na(+)]. This synergism revealed the existence of distinct and cooperative activation mechanisms and a wide dynamic range of ...[more]