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Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early-stage adenocarcinoma of the prostate: long-term results from proton radiation oncology group/american college of radiology 95-09.


ABSTRACT: PURPOSE To test the hypothesis that increasing radiation dose delivered to men with early-stage prostate cancer improves clinical outcomes. PATIENTS AND METHODS Men with T1b-T2b prostate cancer and prostate-specific antigen /= 3 genitourinary toxicity, and 1% of patients in the high-dose arm experienced late grade >/= 3 GI toxicity. CONCLUSION This randomized controlled trial shows superior long-term cancer control for men with localized prostate cancer receiving high-dose versus conventional-dose radiation. This was achieved without an increase in grade >/= 3 late urinary or rectal morbidity.

SUBMITTER: Zietman AL 

PROVIDER: S-EPMC2834463 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early-stage adenocarcinoma of the prostate: long-term results from proton radiation oncology group/american college of radiology 95-09.

Zietman Anthony L AL   Bae Kyounghwa K   Slater Jerry D JD   Shipley William U WU   Efstathiou Jason A JA   Coen John J JJ   Bush David A DA   Lunt Margie M   Spiegel Daphna Y DY   Skowronski Rafi R   Jabola B Rodney BR   Rossi Carl J CJ  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100201 7


PURPOSE To test the hypothesis that increasing radiation dose delivered to men with early-stage prostate cancer improves clinical outcomes. PATIENTS AND METHODS Men with T1b-T2b prostate cancer and prostate-specific antigen </= 15 ng/mL were randomly assigned to a total dose of either 70.2 Gray equivalents (GyE; conventional) or 79.2 GyE (high). No patient received androgen suppression therapy with radiation. Local failure (LF), biochemical failure (BF), and overall survival (OS) were outcomes.  ...[more]

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