Facilitating informed decisions regarding microsatellite instability testing among high-risk individuals diagnosed with colorectal cancer.

ABSTRACT:

Purpose

To evaluate the impact of a CD-ROM intervention in the education of patients with suspected Lynch syndrome (LS) about microsatellite instability (MSI) and immunohisochemistry (IHC) testing.

Patients and methods

Two hundred thirteen patients meeting Bethesda criteria were randomly assigned to receive either a brief educational session with a health educator (n = 105) or a brief educational session plus a CD-ROM (n = 108). Assessments were administered at baseline and 2 weeks post-treatment. Primary outcomes included MSI and IHC knowledge and level of satisfaction with and completeness of the preparation to make the decision for MSI testing. Secondary outcomes included decisional conflict, difficulty making the decision, cancer-specific and global anxiety, and level of

SUBMITTER: Manne SL 

PROVIDER: S-EPMC2834496 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature