Ontology highlight
ABSTRACT:
SUBMITTER: Kaandorp JJ
PROVIDER: S-EPMC2834613 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Kaandorp Joepe J JJ Benders Manon J N L MJ Rademaker Carin M A CM Torrance Helen L HL Oudijk Martijn A MA de Haan Timo R TR Bloemenkamp Kitty W M KW Rijken Monique M van Pampus Maria G MG Bos Arie F AF Porath Martina M MM Oetomo Sidarto Bambang SB Willekes Christine C Gavilanes A W Danilo AW Wouters Maurice G A J MG van Elburg Ruurd M RM Huisjes Anjoke J M AJ Bakker Saskia C M J E R SC van Meir Claudia A CA von Lindern Jeannette J Boon Janine J de Boer Inge P IP Rijnders Robbert Jp RJ Jacobs Corrie J W F M CJ Uiterwaal Cuno S P M CS Mol Ben Willem J BW Visser Gerard H A GH van Bel Frank F Derks Jan B JB
BMC pregnancy and childbirth 20100218
<h4>Background</h4>Hypoxic-ischaemic encephalopathy is associated with development of cerebral palsy and cognitive disability later in life and is therefore one of the fundamental problems in perinatal medicine. The xanthine-oxidase inhibitor allopurinol reduces the formation of free radicals, thereby limiting the amount of hypoxia-reperfusion damage. In case of suspected intra-uterine hypoxia, both animal and human studies suggest that maternal administration of allopurinol immediately prior to ...[more]