Unknown

Dataset Information

0

The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis.


ABSTRACT: The peroxisome proliferator-activated receptor-gamma gene (PPARG) has been implicated in the etiology of type 2 diabetes mellitus and has been investigated in numerous epidemiologic studies. In this Human Genome Epidemiology review, the authors assessed this relation in an updated meta-analysis of 60 association studies. Electronic literature searches were conducted on September 14, 2009. Population-based cohort, case-control, cross-sectional, or genome-wide association studies reporting associations between the PPARG Pro12Ala gene variant (rs1801282) and type 2 diabetes were included. An updated literature-based meta-analysis involving 32,849 type 2 diabetes cases and 47,456 controls in relation to the PPARG Pro12Ala variant was conducted. The combined overall odds ratio, calculated by per-allele genetic model random-effects meta-analysis for type 2 diabetes and the Pro12Ala polymorphism, was 0.86 (95% confidence interval: 0.81, 0.90). The analysis indicated a moderate level of heterogeneity attributable to genuine variation in gene effect size (I(2) = 37%). This may reflect the variation observed between ethnic populations and/or differences in body mass index. Work on PPARG Pro12Ala should now focus on the observed heterogeneity in the magnitude of the association between populations. Further investigations into gene-gene and gene-environment interactions may prove enlightening.

SUBMITTER: Gouda HN 

PROVIDER: S-EPMC2834889 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis.

Gouda Hebe N HN   Sagoo Gurdeep S GS   Harding Anne-Helen AH   Yates Jan J   Sandhu Manjinder S MS   Higgins Julian P T JP  

American journal of epidemiology 20100223 6


The peroxisome proliferator-activated receptor-gamma gene (PPARG) has been implicated in the etiology of type 2 diabetes mellitus and has been investigated in numerous epidemiologic studies. In this Human Genome Epidemiology review, the authors assessed this relation in an updated meta-analysis of 60 association studies. Electronic literature searches were conducted on September 14, 2009. Population-based cohort, case-control, cross-sectional, or genome-wide association studies reporting associa  ...[more]

Similar Datasets

| S-EPMC2453532 | biostudies-literature
| S-EPMC3759498 | biostudies-literature
| S-EPMC3214336 | biostudies-literature
| S-EPMC3611930 | biostudies-literature
| S-EPMC3001974 | biostudies-literature
| S-EPMC5735326 | biostudies-literature
| S-EPMC3683011 | biostudies-literature
| S-EPMC2797971 | biostudies-literature
| S-EPMC6393226 | biostudies-literature
| S-EPMC2938077 | biostudies-literature