Ontology highlight
ABSTRACT:
SUBMITTER: Rogatsky I
PROVIDER: S-EPMC283509 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Rogatsky Inez I Wang Jen-Chywan JC Derynck Mika K MK Nonaka Daisuke F DF Khodabakhsh Daniel B DB Haqq Christopher M CM Darimont Beatrice D BD Garabedian Michael J MJ Yamamoto Keith R KR
Proceedings of the National Academy of Sciences of the United States of America 20031114 24
The glucocorticoid receptor (GR) activates or represses transcription depending on the sequence and architecture of the glucocorticoid response elements in target genes and the availability and activity of interacting cofactors. Numerous GR cofactors have been identified, but they alone are insufficient to dictate the specificity of GR action. Furthermore, the role of different functional surfaces on the receptor itself in regulating its targets is unclear, due in part to the paucity of known ta ...[more]