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Host-guest interaction mediated polymeric assemblies: multifunctional nanoparticles for drug and gene delivery.

ABSTRACT: Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.

SUBMITTER: Zhang J

PROVIDER: S-EPMC2835570 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Host-guest interaction mediated polymeric assemblies: multifunctional nanoparticles for drug and gene delivery.

Zhang Jianxiang J Sun Hongli H Ma Peter X PX

ACS nano 20100201 2

Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarrier ...[more]

PMID: 20112968

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