Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC2836017 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Zhang Hengwei H Cao Rui R Lee Wai-Nang Paul WN Deng Caishu C Zhao Yingchun Y Lappe Joan J Recker Robert R Yen Yun Y Wang Qi Q Tsai Ming-Ying MY Go Vay Liang VL Xiao Gary Guishan GG
Journal of proteome research 20100201 2
Oxythiamine (OT), a transketolase inhibitor, is known to inhibit pancreatic cancer cell proliferation. In this study, we investigated the effect of inhibition of the transketolase pathway on signaling pathways in MIA PaCa cancer cells using in-house proteomic techniques. We hypothesized that OT alter protein phosphorylation thus affecting cell cycle arrest and cell proliferation. MIA PaCa-2 cells were cultured in media containing an algal (15)N amino acid mixture at 50% enrichment, with and with ...[more]