Ontology highlight
ABSTRACT:
SUBMITTER: Shinohara M
PROVIDER: S-EPMC2836054 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Shinohara Masahiro M Adachi Yoshifumi Y Mitsushita Junji J Kuwabara Mitsuhiro M Nagasawa Atsushi A Harada Saori S Furuta Shuichi S Zhang Yugen Y Seheli Kajla K Miyazaki Hitoshi H Kamata Tohru T
The Journal of biological chemistry 20091217 7
A mediating role of the reactive oxygen species-generating enzyme Nox1 has been suggested for Ras oncogene transformation phenotypes including anchorage-independent cell growth, augmented angiogenesis, and tumorigenesis. However, little is known about whether Nox1 signaling regulates cell invasiveness. Here, we report that the cell invasion activity was augmented in K-Ras-transformed normal rat kidney cells and attenuated by transfection of Nox1 small interference RNAs (siRNAs) into the cells. D ...[more]