Ontology highlight
ABSTRACT:
SUBMITTER: Finlin BS
PROVIDER: S-EPMC283615 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20031117 24
Rem, Rem2, Rad, and Gem/Kir (RGK) represent a distinct GTPase family with largely unknown physiological functions. We report here that both Rem and Rad bind directly to Ca2+ channel beta-subunits (CaV beta) in vivo. No calcium currents are recorded from human embryonic kidney 293 cells coexpressing the L type Ca2+ channel subunits CaV1.2, CaV beta 2a, and Rem or Rad, but CaV1.2 and CaV beta 2a transfected cells elicit Ca2+ channel currents in the absence of these small G proteins. Importantly, C ...[more]