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The relationship of DSM-IV personality disorders to nicotine dependence-results from a national survey.

ABSTRACT: This study examined the prevalence of nicotine dependence (ND) and its associations with DSM-IV personality disorders (PDs) among current smokers (n=7078), controlling for sociodemographic characteristics and comorbid Axis I and II disorders. Data were derived from a nationally representative sample of the U.S. population. Although all PDs were significantly associated with ND when sociodemographic factors were controlled, only schizotypal, borderline, narcissistic and obsessive-compulsive PDs were associated with ND after adding controls for Axis I and other Axis II disorders. These associations remained significant after controlling for degree of smoking exposure. The results suggest that both shared and PD-specific pathogenetic factors underlie these PD-ND associations. Implications are also discussed in terms of the relationship between personality features of schizotypal, borderline, narcissistic and obsessive-compulsive PDs and the self-medication hypothesis and the role of neurotransmission.

SUBMITTER: Pulay AJ 

PROVIDER: S-EPMC2836161 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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The relationship of DSM-IV personality disorders to nicotine dependence-results from a national survey.

Pulay Attila J AJ   Stinson Frederick S FS   Ruan W June WJ   Smith Sharon M SM   Pickering Roger P RP   Dawson Deborah A DA   Grant Bridget F BF  

Drug and alcohol dependence 20100115 1-2

This study examined the prevalence of nicotine dependence (ND) and its associations with DSM-IV personality disorders (PDs) among current smokers (n=7078), controlling for sociodemographic characteristics and comorbid Axis I and II disorders. Data were derived from a nationally representative sample of the U.S. population. Although all PDs were significantly associated with ND when sociodemographic factors were controlled, only schizotypal, borderline, narcissistic and obsessive-compulsive PDs w  ...[more]

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