An atlas of combinatorial transcriptional regulation in mouse and man.
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ABSTRACT:
SUBMITTER: Ravasi T
PROVIDER: S-EPMC2836267 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi Timothy T Ravasi Timothy T Suzuki Harukazu H Cannistraci Carlo Vittorio CV Katayama Shintaro S Bajic Vladimir B VB Tan Kai K Akalin Altuna A Schmeier Sebastian S Kanamori-Katayama Mutsumi M Bertin Nicolas N Carninci Piero P Daub Carsten O CO Forrest Alistair R R AR Gough Julian J Grimmond Sean S Han Jung-Hoon JH Hashimoto Takehiro T Hide Winston W Hofmann Oliver O Kamburov Atanas A Kaur Mandeep M Kawaji Hideya H Kubosaki Atsutaka A Lassmann Timo T van Nimwegen Erik E MacPherson Cameron Ross CR Ogawa Chihiro C Radovanovic Aleksandar A Schwartz Ariel A Teasdale Rohan D RD Tegnér Jesper J Lenhard Boris B Teichmann Sarah A SA Arakawa Takahiro T Ninomiya Noriko N Murakami Kayoko K Tagami Michihira M Fukuda Shiro S Imamura Kengo K Kai Chikatoshi C Ishihara Ryoko R Kitazume Yayoi Y Kawai Jun J Hume David A DA Ideker Trey T Hayashizaki Yoshihide Y
Cell 20100301 5
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions a ...[more]
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