Ontology highlight
ABSTRACT:
SUBMITTER: Spiegel I
PROVIDER: S-EPMC2836764 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Nature neuroscience 20070603 7
Myelination in the peripheral nervous system requires close contact between Schwann cells and the axon, but the underlying molecular basis remains largely unknown. Here we show that cell adhesion molecules (CAMs) of the nectin-like (Necl, also known as SynCAM or Cadm) family mediate Schwann cell-axon interaction during myelination. Necl4 is the main Necl expressed by myelinating Schwann cells and is located along the internodes in direct apposition to Necl1, which is localized on axons. Necl4 se ...[more]