In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging.
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ABSTRACT:
SUBMITTER: Evans CL
PROVIDER: S-EPMC2836890 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging.
Evans Conor L CL Rizvi Imran I Hasan Tayyaba T de Boer Johannes F JF
Optics express 20090501 11
In vitro three-dimensional models for metastatic ovarian cancer have been useful for recapitulating the human disease. These spheroidal tumor cultures, however, can grow in excess of 1 mm in diameter, which are difficult to visualize without suitable imaging technology.Optical coherence tomography (OCT) is an ideal live imaging method for non-perturbatively visualizing these complex systems. OCT enabled detailed observations of the model at both nodular and cellular levels, revealing growth dyna ...[more]
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