Ontology highlight
ABSTRACT:
SUBMITTER: Singh AP
PROVIDER: S-EPMC2836945 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Singh A P AP Harada S S Mishina Y Y
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20090401 1
Sertoli cells provide nutritional and physical support to germ cells during spermatogenesis. Sox8 encodes a high mobility group transcription factor closely related to Sox9 and Sox10. Sertoli cells produceSOX8 protein, and its elimination results in an age-dependent deregulation of spermatogenesis resulting in male infertility. This suggests that Sox8 is a critical regulator of Sertoli cell function for the maintenance of male fertility beyond the first wave of spermatogenesis. To better underst ...[more]