Ontology highlight
ABSTRACT:
SUBMITTER: Quraishi S
PROVIDER: S-EPMC2837113 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Quraishi S S Reed B T BT Duvoisin R M RM Taylor W R WR
Neuroscience 20100120 3
Extracellular and whole-cell light-evoked responses of mouse retinal ganglion cells were recorded in the presence of the mGluR8 selective agonist, (S)-3,4-dicarboxy-phenylglycine (DCPG). Off-light responses were reversibly reduced in the presence of DCPG in wild-type but not in mGluR8-deficient retinas. On-responses were only marginally modulated by DCPG. During Off-responses, DCPG suppressed both excitatory and inhibitory synaptic conductances suggesting that mGluR8 receptor activity reduces gl ...[more]