Ontology highlight
ABSTRACT:
SUBMITTER: Moyer AM
PROVIDER: S-EPMC2837367 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Moyer Ann M AM Sun Zhifu Z Batzler Anthony J AJ Li Liang L Schaid Daniel J DJ Yang Ping P Weinshilboum Richard M RM
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20100303 3
<h4>Background</h4>Lung cancer is commonly treated with platinum compounds. The "glutathione pathway" participates in the metabolism of platinum compounds. We set out to test the hypotheses that single nucleotide polymorphisms (SNPs) or copy number polymorphisms for genes within the glutathione pathway might influence survival in lung cancer patients treated with these drugs.<h4>Methods</h4>Germline DNA samples from 973 lung cancer patients were genotyped for 290 glutathione pathway SNPs. GSTT1 ...[more]