Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks.
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ABSTRACT:
SUBMITTER: He X
PROVIDER: S-EPMC2837480 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks.
He Xionglei X Qian Wenfeng W Wang Zhi Z Li Ying Y Zhang Jianzhi J
Nature genetics 20100124 3
Epistasis refers to the interaction between genes. Although high-throughput epistasis data from model organisms are being generated and used to construct genetic networks, the extent to which genetic epistasis reflects biologically meaningful interactions remains unclear. We have addressed this question through in silico mapping of positive and negative epistatic interactions amongst biochemical reactions within the metabolic networks of Escherichia coli and Saccharomyces cerevisiae using flux b ...[more]
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