Ontology highlight
ABSTRACT:
SUBMITTER: Brak K
PROVIDER: S-EPMC2838180 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20100201 4
A century after discovering that the Trypanosoma cruzi parasite is the etiological agent of Chagas disease, treatment is still plagued by limited efficacy, toxicity, and the emergence of drug resistance. The development of inhibitors of the major T. cruzi cysteine protease, cruzain, has been demonstrated to be a promising drug discovery avenue for this neglected disease. Here we establish that a nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitor substantially ameliorates symptoms of a ...[more]