Ontology highlight
ABSTRACT:
SUBMITTER: Vilgelm AE
PROVIDER: S-EPMC2838189 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Vilgelm Anna E AE Washington Mary K MK Wei Jinxiong J Chen Heidi H Prassolov Vladimir S VS Zaika Alexander I AI
Molecular cancer therapeutics 20100302 3
p53, p63, and p73 are members of the p53 protein family involved in regulation of cell cycle, apoptosis, differentiation, and other critical cellular processes. Here, we investigated the contribution of the entire p53 family in chemotherapeutic drug response in gastrointestinal tumors. Real-time PCR and immunohistochemistry revealed complexity and variability of expression profiles of the p53 protein family. Using colon and esophageal cancer cells, we found that the integral transcription activi ...[more]