Autophagy in hypertensive heart disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Wang ZV
PROVIDER: S-EPMC2838272 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Autophagy in hypertensive heart disease.
Wang Zhao V ZV Rothermel Beverly A BA Hill Joseph A JA
The Journal of biological chemistry 20100129 12
In response to hypertension, the heart manifests robust hypertrophic growth, which offsets load-induced elevations in wall stress. If sustained, this hypertrophic response is a major risk factor for systolic dysfunction and heart failure. Extensive research efforts have focused on the progression from hypertrophy to failure; however, precise understanding of underlying mechanisms remains elusive. Recently, autophagy, a process of cellular cannibalization, has been implicated. Autophagy is activa ...[more]
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