Ontology highlight
ABSTRACT:
SUBMITTER: Chander H
PROVIDER: S-EPMC2838694 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Chander Harish H Halpern Max M Resnick-Silverman Lois L Manfredi James J JJ Germain Doris D
EMBO reports 20100205 3
The F-box protein Skp2 and its isoform Skp2B are both overexpressed in breast cancers. Skp2 alters the activity of p53 by inhibiting its interaction with p300 and by promoting p300 degradation. Here, we report that Skp2B also attenuates the activity of p53; however, this effect is independent of p300, suggesting that another mechanism might be involved. Prohibitin, a protein reported to activate p53, was isolated in a two-hybrid screen with the carboxy-terminal domain unique to Skp2B. We observe ...[more]