Chemical biology studies on norrisolide.
Ontology highlight
ABSTRACT:
SUBMITTER: Guizzunti G
PROVIDER: S-EPMC2838712 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Chemical biology studies on norrisolide.
Guizzunti Gianni G Brady Thomas P TP Fischer Derek D Malhotra Vivek V Theodorakis Emmanuel A EA
Bioorganic & medicinal chemistry 20100210 6
The cellular activity of norrisolide (7), a novel Golgi-vesiculating agent, was dissected as function of its chemical structure. This natural product induces irreversible vesiculation of the Golgi membranes and blocks protein transport at the level of the Golgi. The Golgi localization and fragmentation effects of 7 depend on the presence of the perhydroindane core, while the irreversibility of fragmentation depends on the acetyl group of 7. We show that fluorescent derivatives of norrisolide are ...[more]
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