Ontology highlight
ABSTRACT:
SUBMITTER: Ji Y
PROVIDER: S-EPMC2838738 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Ji Yanli Y Jia Xiaoyun X Li Shiqiang S Xiao Xueshan X Guo Xiangming X Zhang Qingjiong Q
Molecular vision 20100311
<h4>Purpose</h4>To test the association of the X-chromosome regions (Xp21.1-q21.2 and Xq25-27.2) with Leber hereditary optic neuropathy (LHON) in Chinese patients.<h4>Methods</h4>One hundred and seventy-five male LHON patients with the G11778A mutation and 100 unrelated normal males participated. Twelve microsatellite markers and four single-nucleotide polymorphisms (SNPs) were genotyped for patients and controls. A chi(2) or Fisher's exact test was used to compare the frequencies of genotypes a ...[more]