Ontology highlight
ABSTRACT:
SUBMITTER: Cai Q
PROVIDER: S-EPMC2838797 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
PloS one 20100316 3
The hypoxic microenvironment contributes to embryonic development and tumor progression through stabilization of the potent transcriptional factor HIFalpha. In normoxia, the tumor suppressor protein VHL acts as an E3 ubiquitin ligase to target HIFalpha for proteolytic destruction. Increasing evidence shows that VHL is a multifunctional adaptor involved in inhibition of HIFalpha-dependent and independent cellular processes. However, the molecular effect of hypoxic stress on VHL functions remains ...[more]