Unknown

Dataset Information

0

High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleus.


ABSTRACT: In this work, we exploited the superior capability of high-resolution functional magnetic resonance imaging (fMRI) for functional mapping of ocular dominance layer (ODL) in the cat lateral geniculate nucleus (LGN). The stimulus-evoked neuronal activities in the LGN ODLs associated with contralateral- and ipsilateral-eye visual inputs were successfully differentiated and mapped using both blood-oxygenation-level dependent (BOLD)-weighted and cerebral blood volume (CBV)-weighted fMRI methods. The morphology of mapped LGN ODLs was in remarkable consistency with histology findings in terms of ODL shape, orientation, thickness and eye-dominance. Compared with the BOLD signal, the CBV signal provides higher reproducibility and better spatial resolvability for function mapping of LGN because of improved contrast-to-noise ratio and point-spread function. The capability of fMRI for non-invasively imaging the functional sub-units of ODL in a small LGN overcomes the limitation of conventional neural-recording approach, and it opens a new opportunity for studying critical roles of LGN in brain function and dysfunction at the fine scale of ocular dominance layer.

SUBMITTER: Zhang N 

PROVIDER: S-EPMC2838974 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleus.

Zhang Nanyin N   Zhu Xiao-Hong XH   Zhang Yi Y   Park Jae-keun JK   Chen Wei W  

NeuroImage 20100128 4


In this work, we exploited the superior capability of high-resolution functional magnetic resonance imaging (fMRI) for functional mapping of ocular dominance layer (ODL) in the cat lateral geniculate nucleus (LGN). The stimulus-evoked neuronal activities in the LGN ODLs associated with contralateral- and ipsilateral-eye visual inputs were successfully differentiated and mapped using both blood-oxygenation-level dependent (BOLD)-weighted and cerebral blood volume (CBV)-weighted fMRI methods. The  ...[more]

Similar Datasets

| S-EPMC7211434 | biostudies-literature
| S-EPMC8549691 | biostudies-literature
| S-EPMC2904843 | biostudies-literature
| S-EPMC7072923 | biostudies-literature
| S-EPMC2777261 | biostudies-other
| S-EPMC3741618 | biostudies-literature
| S-EPMC4556110 | biostudies-literature
| S-EPMC6992387 | biostudies-literature
| S-EPMC1470662 | biostudies-literature
| S-EPMC3517882 | biostudies-literature