Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
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ABSTRACT:
SUBMITTER: Tang X
PROVIDER: S-EPMC2839190 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
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Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Tang Xiaoling X Jang Sung-Wuk SW Okada Masashi M Chan Chi-Bun CB Feng Yue Y Liu Yu Y Luo Shi-Wen SW Hong Yan Y Rama Nicolas N Xiong Wen-Cheng WC Mehlen Patrick P Ye Keqiang K
Nature cell biology 20080511 6
Netrins, a family of secreted molecules, have critical functions in axon guidance and cell migration during neuronal development. In addition to its role as a chemotropic molecule, netrin-1 also acts as a survival factor. Both UNC5 (that is, UNC5A, UNC5B, UNC5C or UNC5D) and DCC are transmembrane receptors for netrin-1 (Refs 8, 9). In the absence of netrin-1, DCC and UNC5 act as dependence receptors and trigger apoptosis. However, how netrin-1 suppresses the apoptotic activity of the receptors r ...[more]
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