Ontology highlight
ABSTRACT:
SUBMITTER: Chen M
PROVIDER: S-EPMC2839444 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Chen Min M Matsuda Hiroyuki H Wang Linghua L Watanabe Takayoshi T Kimura Makoto T MT Igarashi Jun J Wang Xiaofei X Sakimoto Tohru T Fukuda Noboru N Sawa Mitsuru M Nagase Hiroki H
Molecular therapy : the journal of the American Society of Gene Therapy 20091117 3
Corneal alkali burns are a serious clinical problem that often leads to permanent visual impairment. In this process, transforming growth factor (Tgf)-beta1 is upregulated and involved in the response to corneal injury and the process of corneal stromal scarring. To develop an efficient compound to inhibit Tgf-beta1 in the cornea, we designed GB1201, a pyrrole-imidazole (PI) polyamide targeting rat Tgf-beta1 gene promoter to the activator protein-1 (AP-1) binding site. GB1201 showed a high bindi ...[more]