Ontology highlight
ABSTRACT:
SUBMITTER: Terracciano A
PROVIDER: S-EPMC2840212 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Terracciano Antonio A Tanaka Toshiko T Sutin Angelina R AR Deiana Barbara B Balaci Lenuta L Sanna Serena S Olla Nazario N Maschio Andrea A Uda Manuela M Ferrucci Luigi L Schlessinger David D Costa Paul T PT
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20091230 5
Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurotransmission, and has been linked to neuroticism, a major risk factor for psychiatric disorders. A recent genome-wide association (GWA) scan, however, found the BDNF Val66Met polymorphism (rs6265) associated with extraversion but not with neuroticism. In this study, we examine the links between BDNF and personality traits, assessed using the Revised NEO Personality Inventory (NEO-PI-R), in a sample from SardiNIA (n=1 ...[more]