Ontology highlight
ABSTRACT:
SUBMITTER: Stetler RA
PROVIDER: S-EPMC2840276 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Stetler R Anne RA Gao Yanqin Y Zukin R Suzanne RS Vosler Peter S PS Zhang Lili L Zhang Feng F Cao Guodong G Bennett Michael V L MV Chen Jun J
Proceedings of the National Academy of Sciences of the United States of America 20100201 7
Inducible DNA repair via the base-excision repair pathway is an important prosurvival mechanism activated in response to oxidative DNA damage. Elevated levels of the essential base-excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1)/redox effector factor-1 correlate closely with neuronal survival against ischemic insults, depending on the CNS region, protective treatments, and degree of insult. However, the precise mechanisms by which this multifunctional protein affords protectio ...[more]